Oncolytic Adenoviruses in Cancer Treatment
نویسندگان
چکیده
منابع مشابه
Oncolytic Adenoviruses in Cancer Treatment
The therapeutic use of viruses against cancer has been revived during the last two decades. Oncolytic viruses replicate and spread inside tumors, amplifying their cytotoxicity and simultaneously reversing the tumor immune suppression. Among different viruses, recombinant adenoviruses designed to replicate selectively in tumor cells have been clinically tested by intratumoral or systemic adminis...
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Metastatic cancer remains difficult to treat effectively and treatments are in most cases not curative despite significant side effects. Novel, targeted approaches such as gene therapy hold promise for the treatment of various tumor types. Among the most promising cancer gene therapy approaches are oncolytic adenoviruses, which are able to infect, replicate in and lyse tumor cells. Recent data ...
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ژورنال
عنوان ژورنال: Biomedicines
سال: 2014
ISSN: 2227-9059
DOI: 10.3390/biomedicines2010036